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Old Nov 20th 2017, 03:06 AM   #1
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Dissociation of weak acids


As a dietitian, I was taught during my training that weak acids never dissociate all at the same time, and that at any given point in time, some of it remains in acide form while the rest is deprotonized.

Could anyone confirm that this is the case? Especially for lactic acid/lactate, which at blood pH is supposed to be almost entirely deprotonized in lactate form. Is it possible for ionized lactate (produced during fermentation) to regain a proton and transform back into lactic acid, even if blood pH is around 7,4 and the pKa for lactic acid is around 3,7 ?

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